Innovation
Last week (18 October 2024), the Department of Health and Social Care, the Office for Life Sciences and the Department for Science, Innovation and Technology announced that the Government has awarded £12 million to projects across the UK that are researching innovative technology to support people with addictions.
The research is being funded through the Addiction Healthcare Goals programme, which is run by the Office for Life Sciences (OLS). Around £12 million has been awarded to 11 projects across eight organisations in the UK. The projects were selected as part of the Reducing Drug Deaths Challenge and the NIHR i4i Addiction: Innovation for Treatment and Recovery Awards, which are being run in partnership with the Scottish government and National Institute for Health and Care Research (NIHR). Several of the projects are based in Scotland which has the highest rate of drug deaths in Europe.
Below, I provide basic information on some of the projects funded.
Reducing Drug Deaths Innovation Challenge
Pneumowave ALERT
PneumoWave ALERT is a remote monitoring platform designed to make opioid usage safer by detecting the onset of life-threatening respiratory problems caused by opioid-induced overdose. The platform consists of a discreet, chest-worn biosensor paired with a mobile device, which allows for the immediate alerting of nearby naloxone carriers and emergency medical services. The research involves conducting end-to-end monitoring, detection, and alerting in 200 high-risk patients residing in homeless accommodation, in collaboration with the University of Dundee, King’s College London, and Third Sector partners HumanKind, Thames Reach, and Hillcrest Futures.
NOMW Health
NOMW Health, in collaboration with Greater Glasgow and Clyde Innovation Hub and The University of Southampton, previously conducted a feasibility study on LifeSavr, an innovative wearable device aimed at addressing the opioid overdose crisis. The Scotland-based team is now advancing the development of LifeSavr to prepare it for consumer availability in the UK, Europe, and globally. LifeSavr features monitoring of oxygen saturation, heart rate, body movements and respiratory rate for accurate overdose detection. It is based on NASA research and uses a self-contained design that eliminates the need for a mobile phone. The device aims to reduce the burden on emergency services and long-term care.
Kings College London
Kings College London is developing rapid-dispersal naloxone wafers to improve the accessibility and portability of this life-saving emergency antidote medication. Naloxone rapidly reverses heroin/opioid overdose, but current forms (injection and nasal spray) have limitations, such as requiring healthy nasal passages and consistent carrying by users. The proposed naloxone wafers disintegrate within seconds and can easily fit into a wallet or purse, addressing the current low carriage rates which are around 15-20%.
NIHR i4i Addiction Innovation: Innovation for Treatment and Recovery Awards
Kings College London – is developing a Virtual Reality-enhanced cue exposure treatment integrated with a wearable device to address craving, prevent relapse and improve treatment outcomes of people with cocaine dependence.
A key challenge in helping people to recover for cocaine addiction (or dependence) is their craving for the drug that can be triggered by ‘cues’ in their environment, such as situations or objects, which remind them of the pleasurable effects of cocaine. This process is known as ‘classical conditioning’ and the aim of this study is to reduce the risk of relapse to cocaine through use of novel technologies to reduce craving. This research will test the ability of technology-enhanced CET to reduce craving and relapse to cocaine use, compared to people receiving usual care.
Another project led by Kings College London, The Prison Release Engagement Trial will refine and test an interactive smartphone app to improve Continuity of Care post-release for prisoners working to stay drug free.
Future research
Alongside funding innovative research, the Addiction Healthcare Goals programme is aiming to support the training of research leaders across the UK and is exploring ways to make better use of addiction healthcare data to enable researchers to develop better treatments. The programme has also been working with the James Lind Alliance to identify the key research priorities within the UK community and will be publishing this list in 2025 with the aim of influencing future research funding priorities.
